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The XY sex-determination system is the sex-determination system found in humans, most other mammals, some insects (), some snakes, and some plants ().In this system, the sex of an individual is determined by a pair of sex chromosomes.

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Sex chromosome: Sex chromosome, either of a pair of chromosomes that determine whether an individual is male or female. The sex chromosomes of human beings and other mammals are designated by scientists as X and Y.

Beyond XX and XY: The Extraordinary Complexity of Sex Determination. A host of factors figure into whether someone is female, male or somewhere in between